The advent of Artificial Intelligence (AI) has brought transformative changes to various sectors, and the healthcare is no exception. This paper thematically assesses the impact of AI on patient- healthcare provider communication, specifically focusing on enhancing health information exchange and decision-making in the digital era. As technology evolves, the healthcare landscape is witnessing a paradigm shift towards more efficient and personalized approaches. AI’s integration into healthcare systems has paved the way for advanced health information exchange. Through intelligent algorithms and data analytics, AI facilitates the seamless flow of information between patients and providers, fostering a more comprehensive understanding of individual health profiles. This exchange empowers healthcare professionals with timely and relevant data, allowing for more informed decision- making. In the realm of patient- healthcare provider communication, AI plays a pivotal role in optimizing interactions. However, as the healthcare sector embraces AI, challenges such as data privacy, ethical considerations, and the need for standardized protocols must be addressed especially in a country like Nigeria. Striking a balance between technological advancements and ethical guidelines is crucial to harness the full potential of AI in patient- provider communication. This paper concludes that, the integration of AI in healthcare is reshaping patient- healthcare provider communication by improving health information exchange and decision-making. While presenting unprecedented opportunities, it is essential to navigate ethical considerations and ensure a harmonious coexistence of technology and human-centric healthcare delivery in the digital era. Keywords: artificial intelligence, chatbots, communication, digital era, health, patient- healthcare provider.